Why Use Zebra Fish Brain in the USA


It is highly validated as a powerful vertebrate model for investigating human neurodegenerative diseases. The neuroanatomic and neurochemical pathways of zebrafish brain exhibit a profound resemblance with the human brain.

Why are zebra fish used in research?

Zebrafish embryos are nearly transparent which allows researchers to easily examine the development of internal structures. Zebrafish have a similar genetic structure to humans. They share 70 per cent of genes with us. 84 per cent of genes known to be associated with human disease have a zebrafish counterpart.

Why is zebrafish a good NCBI model?

Zebrafish has proven to be a good model to predict adverse drug effects during animal preclinical and human clinical data [109]. This is because many of the cellular and molecular mechanisms involved in zebrafish’s response to toxicity or stress are similar to those of mammals [110,111].

Do zebra fish have brains?

What is beginning to emerge is that similar to other mammals, adult zebrafish have an integrated nervous system, which is proposed to contain homologous brain structures to those found in humans, as well as equivalent cellular and synaptic structure and function.

What are the disadvantages of using zebrafish for research?

Disadvantages: They require water systems to maintain them. They are not mammals and are not as closely related to humans as a mouse is. Reverse genetics has not been worked out for zebrafish as it has in the mouse.

How much DNA do we share with zebrafish?

Humans and zebrafish share 70 percent of the same genes and 84 percent of human genes known to be associated with human disease have a counterpart in zebrafish.

Where do zebra fish come from?

The zebrafish – Danio rerio – is a tropical freshwater fish originally found in Eastern India’s Ganges River and native to the southeastern Himalayan region. The vertebrate takes its name from the horizontal blue stripes running the length of its body.

Why zebrafish are better than mice?

While mice are evolutionarily more similar to humans because they are mammals, zebrafish have several advantages over their furry competitors. One important advantage of zebrafish is that the adults are small and prefer to be housed in large groups, or “shoals”. Working with mice in this way is much more complicated.

Why do zebrafish develop so fast?

Maturation and growth rate During zebrafish development, the rate of zebrafish growth is influenced by many factors: water quality, temperature, genetics, food quality and availability, and population density. Even zebrafish grown in standardized conditions show a range of sizes and maturation states as they age (Fig.

How do zebra fish help your eyesight?

“You can blind or seriously damage a zebrafish, and they will regrow their eye in a matter of weeks,” says James Patton, a biologist at Vanderbilt University. The fish can do this because of those Müller glia cells in the retina. Behaving like stem cells, they can regrow the retina and replace all the damaged neurons.

What does zebra fish eat?

General observations and gut content analyses indicated that zebrafish consume a wide variety of animal and plant matter, including zooplankton and insects, phytoplankton, filamentous algae and vascular plant material, spores and invertebrate eggs, fish scales, arachnids, detritus, sand, and mud.

How are zebrafish related to humans?

Humans and zebrafish share 70 percent of the same genes and 84 percent of human genes known to be associated with human disease have a counterpart in zebrafish. Major organs and tissues are also common. Zebrafish genome has also been fully sequenced to a very high quality.

Can zebrafish regenerate cells?

Adult zebrafish are able to regenerate different organs, including all fins (32), the spinal cord (33), the retina (34), the heart (35), the telencephalon (36), and the kidney (37). Interestingly, the mechanisms that control regeneration seem to be organ-specific.

Can zebra Danios get pregnant?

No, the zebra danio is an egg-laying species. When we say “pregnant,” we mean “with eggs and ready to spawn.” In the wild, this species spawns during the monsoon season, when the increase in rainfall results in a change in the water temperature. More on how that relates to breeding them in captivity below.

How many eggs do zebrafish lay?

After 3 – 4 months zebrafish are sexually mature and can generate new offspring. A single female can lay up to 200 eggs per week.

How do zebrafish lay eggs?

At the onset of the light cycle, zebrafish will generally initiate breeding behavior that results in the laying and fertilization of eggs. In a tank that has been marbled, the eggs collect between the marbles and escape predation. However, when no marbles are in the tank, the fish will rapidly consume the eggs.

What is special about zebrafish?

Because of its fully sequenced genome, easy genetic manipulation, high fecundity, external fertilization and rapid development, and nearly transparent embryo, zebrafish are a unique model animal for biomedical research, including studies of biological processes and human diseases.

How many genes does a zebrafish have?

Zebrafish possess 26,206 protein-coding genes6, more than any previously sequenced vertebrate, and they have a higher number of species-specific genes in their genome than do human, mouse or chicken. Some of this increased gene number is likely to be a consequence of the TSD.

Why are zebrafish commonly being used to test new human drugs?

As a toxicology model, zebrafish has the potential to reveal the pathways of developmental toxicity due to their similarity with those of mammals. Zebrafish therefore, provides a sound basis for the risk assessment of drug administration in humans.

Do zebra fish eat other fish?

Zebrafish are omnivorous, primarily eating zooplankton, phytoplankton, insects and insect larvae, although they can eat a variety of other foods, such as worms and small crustaceans, if their preferred food sources are not readily available. In research, adult zebrafish are often fed with brine shrimp, or paramecia.

Can zebrafish be aggressive?

Despite the fact that zebrafish is a gregarious species that forms shoals, when allowed to interact in pairs, both males and females express aggressive behavior and establish dominance hierarchies.

How much DNA we have in common with chimps and zebrafish?

According to one source, we share about 98 per cent of our DNA with chimpanzees, 85 per cent with the zebrafish and 36 per cent with a fruit fly.

Can zebrafish cure blindness?

Except for one cell called MG for muller glia. In a zebrafish when that cell is damaged, it will activate and then regenerate. “So, the fish will go from blind to about two-and-a-half weeks later, total regain of eyesight,” Patton said.

By kevin

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